Product Name :
25-Hydroxycholesterol (CAS 2140-46-7)
Synonym :
5-Cholestene-3β,25-diol; (3β)-Cholest-5-ene-3,25-diol; Cholest-5-ene-3β,25-diol; 25-Hydroxy-5-cholestene-3β-ol
Application :
25-Hydroxycholesterol is an activator of caspases and Bcl-2 expressor
CAS:
2140-46-7
Purity:
≥98%
Molecular Weight:
402.65
Formula :
C27H46O2
Physical state:
Solid
solubility :
Soluble in chloroform
Shipping Condition :
Store at room temperature
Melting point:
SMILES:
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
References:
:Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. | Adams, CM., et al. 2004. J Biol Chem. 279: 52772-80. PMID: 1545213025-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. | Bauman, DR., et al. 2009. Proc Natl Acad Sci U S A. 106: 16764-9. PMID: 19805370On the formation and possible biological role of 25-hydroxycholesterol. | Diczfalusy, U. 2013. Biochimie. 95: 455-60. PMID: 22732193Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation. | Ren, S. and Ning, Y. 2014. Am J Physiol Endocrinol Metab. 306: E123-30. PMID: 2430200925-Hydroxycholesterol acts as an amplifier of inflammatory signaling. | Gold, ES., et al. 2014. Proc Natl Acad Sci U S A. 111: 10666-71. PMID: 24994901Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. | Reboldi, A., et al. 2014. Science. 345: 679-84. PMID: 2510438825-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.Price of 1196154-13-8 | Li, C.1460-59-9 Chemical name , et al.PMID:33390056 2017. Immunity. 46: 446-456. PMID: 2831459325-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor. | Zu, S., et al. 2020. Cell Res. 30: 1043-1045. PMID: 32811977Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival. | Cao, Q., et al. 2020. Oxid Med Cell Longev. 2020: 8893305. PMID: 3327401025-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties. | Domingues, MM., et al. 2021. Int J Mol Sci. 22: PMID: 33806504Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. | Limbad, C., et al. 2022. iScience. 25: 103848. PMID: 35198901TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. | Watson, KE., et al. 1994. J Clin Invest. 93: 2106-13. PMID: 8182141