Product Name :
2-Pyrrolidinone (CAS 616-45-5)
Synonym :
Application :
CAS:
616-45-5
Purity:
≥99%
Molecular Weight:
85.10
Formula :
C4H7NO
Physical state:
Liquid
solubility :
Soluble in benzene (miscible), carbon disfulfide (miscible), chloroform (miscible), ethanol (miscible), and ethyl acetate (miscible).
Shipping Condition :
Store at room temperature
Melting point:
23-25° C (lit.)
SMILES:
C1CC(=O)NC1
References:
:The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. | Nishizaki, T. and Matsumura, T. 2002. Brain Res Mol Brain Res. 98: 130-4. PMID: 118343042-pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs. | Scapecchi, S., et al. 2003. Farmaco. 58: 715-22. PMID: 136791652-pyrrolidinone induces a long-lasting facilitation of hippocampal synaptic transmission by enhancing alpha7 ACh receptor responses via a PKC pathway. | Miyamoto, H., et al. 2003. Brain Res Mol Brain Res. 117: 91-6. PMID: 14499485Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat. | Midgley, I., et al. 1992. Food Chem Toxicol. 30: 57-64. PMID: 1544607Validated hydrophilic interaction LC-MS/MS method for determination of 2-pyrrolidinone residue: applied to a depletion study of 2-pyrrolidinone in swine liver. | Liu, Y., et al. 2011. Anal Bioanal Chem. 399: 1371-80. PMID: 21116620rac-Methyl (3aR*,4S*,5R*,7aR*)-5,7a-bis-(acet-yloxy)-3-oxo-2-phenyl-octa-hydro-1H-iso-indole-4-carboxyl-ate. | Toze, FA., et al. 2013. Acta Crystallogr Sect E Struct Rep Online. 69: o1555. PMID: 240982372-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis. | Kennedy, AD., et al. 2019. Front Neurosci. 13: 394. PMID: 31133775One-Pot Enantioselective Synthesis of 2-Pyrrolidinone Derivatives Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter. | Jia, Z., et al. 2019. Org Lett. 21: 9584-9588. PMID: 31746209Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.3-(Trimethylsilyl)-2-propyn-1-ol In stock | Gerokonstantis, DT.4-Tetrahydrothiopyranone 1,1-dioxide Chemscene , et al.PMID:33630474 2020. Bioorg Med Chem. 28: 115216. PMID: 31864778Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors. | Sasaki, Y., et al. 2020. Bioorg Med Chem Lett. 30: 126963. PMID: 31980341Corrigendum: 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis. | Kennedy, AD., et al. 2019. Front Neurosci. 13: 1344. PMID: 320821032-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid. | Haegele, KD., et al. 1987. J Neurochem. 49: 1402-6. PMID: 36685312-Pyrrolidinone and succinimide endogenously present in several mammalian species. | Bandle, EF., et al. 1984. Life Sci. 35: 2205-12. PMID: 6503611