Product Name :
USP21 Mouse Monoclonal Antibody [16E1]
Predicted band size :
Observed band size :
Synonyms:
Deubiquitinating enzyme 21 antibody deubiquitinating enzyme 23 antibody EC 3.1.2.15 antibody ESTM28 antibody MGC3394 antibody NEDD8-specific protease antibody Ubiquitin carboxyl terminal hydrolase 21 antibody ubiquitin carboxyl terminal hydrolase 23 antibody Ubiquitin carboxyl-terminal hydrolase 21 antibody ubiquitin specific peptidase 21 antibody 展开
Function :
USP21 (Ubiquitin Specific Peptidase 21) is a Protein Coding gene.939793-16-5 Data Sheet Diseases associated with USP21 include Neurodevelopmental Disorder With Spasticity And Poor Growth.1240587-88-5 manufacturer Among its related pathways are TNF signaling (REACTOME) and Integrated Breast Cancer Pathway.PMID:33688977 Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and cysteine-type peptidase activity. An important paralog of this gene is USP2. Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ‘Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein within Human USP21 aa 303-453 / 565.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
16E1
RRID:
AB_3068882
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 63 kDa
Positive control :
SH-SY5Y cell lysates, K562 cell lysates, 293T, rat seminal vesicle tissue, human liver tissue, human kidney tissue, human small intestine tissue, mouse heart tissue, SH-SY5Y cells.