Product Name :
TSHR Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
CHNG1 antibody hTSHR I antibody hTSHRI antibody LGR 3 antibody LGR3 antibody MGC75129 antibody Seven transmembrane helix receptor antibody Thyroid adenoma hyperfunctioning antibody Thyroid carcinoma with thyrotoxicosis antibody Thyroid stimulating hormone receptor antibody 展开
Function :
Various hormones are secreted from the anterior pituitary during development and growth, including thyroid-stimulating hormone (TSH, also known as thyrotropin), follicle-stimulating hormone (FSH) and leutinizing hormone (LH).4-Oxotetrahydrofuran-3-carbonitrile supplier TSH, FSH, and LH are heterodimers formed from a common alpha chain and a unique beta chain. TSH is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones.Fmoc-N-Me-Glu(OtBu)-OH Purity TSH is regulated by thyroid hormone (T3) and various retinoid compounds.PMID:33590797 TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human TSHR 501-600/764
Species reactivity:
Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep
Verify application:
ELISA
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
1:5000-10000
Molecular weight :
86 KDa
Positive control :
Expressed in the thyroid.