Product Name :
TAB1 Mouse Monoclonal Antibody [1G2]
Predicted band size :
Observed band size :
Synonyms:
2310012M03Rik antibody 3′-Tab1 antibody MAP3K7IP 1 antibody MAP3K7IP1 antibody MGC57664 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody TAB 1 antibody TAB1 antibody TAB1_HUMAN antibody 展开
Function :
The TAK1 binding proteins, TAB1, TAB2 and TAB3, interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGFβ mediated signaling.Methanesulfonohydrazide Formula TAB1 also plays a central role in a p38α activation pathway that is independent of MAPKK. In response to pro-inflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1.1934533-59-1 Purity When overexpressed, TAB3 activates both NFκB and AP-1 transcription factors.PMID:33682477 In response to TNFα or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
peptide
Species reactivity:
Human
Verify application:
WB, IP, IF
Coupling :
unconjugated
Clone number:
1G2
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃
Storage buffer solution:
1.0 ml of PBS with
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
56kDa
Positive control :
293T