Product Name :
Scramblase 1 Rabbit Polyclonal Antibody
Predicted band size :
35 kDa
Observed band size :
35 kDa
Synonyms:
Ca(2+) dependent phospholipid scramblase 1 antibody Ca(2+)-dependent phospholipid scramblase 1 antibody Erythrocyte phospholipid scramblase antibody MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of antibody MmTRA1a antibody MmTRA1b antibody Nor1 antibody Phospholipid scramblase 1 antibody PL scramblase 1 antibody PLS1_HUMAN antibody 展开
Function :
Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5.1233717-68-4 web Phospholipid scramblase 1 (PLSCR1), a lipid-binding protein that enters the nucleus via the nonclassical NLS (257)GKISKHWTGI(266). The structure of the nuclear localisation sequence of scramblase PLSCR1 complexed to importin was determined using X-ray diffraction with a resolution of 2.1,1′-(1,3-Phenylene)diethanone web 20 Ångströms. It is found in most mammals including humans. The import sequence lacks a continuous stretch of positively charged residues, and it is enriched in hydrophobic residues. Thus, Scramblase can transport negatively charged phospholipids from the inside of the cell to the outside of the cell. The importin structure is composed of many alpha helices that integrate the protein into membranes. The role of importin is to move proteins such as scramblase into the nucleus.PMID:33495303
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within N-terminal human Scramblase 1.
Species reactivity:
Human
Verify application:
WB, IF-Cell, IHC-P, FC, IP
Coupling :
unconjugated
Clone number:
RRID:
AB_3071162
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 35 kDa
Positive control :
SK-MEL-28 cell lysate, HeLa cell lysate, THP-1 cell lysate, MDA-MB-231 cell lysate, HUVEC, human tonsil tissue, SK-MEL-28.