Product Name :
ZBTB48 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
0610011D15Rik antibody AI327031 antibody GLI Kruppel family member HKR3 antibody HKR3 antibody Krueppel related zinc finger protein 3 antibody Krueppel-related zinc finger protein 3 antibody OTTMUSP00000031803 antibody pp9964 antibody Protein HKR3 antibody RP23-445E20.3 antibody 展开
Function :
Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that directly binds to the double-stranded repeat sequence of telomeres. In humans it is encoded by the ZBTB48 gene. Loss of ZBTB48 has been shown to lead to telomere elongation both in cells with long and short telomeres. In addition, overexpression of ZBTB48 in cancer cells maintaining their telomeres based on the Alternative Lengthening of Telomeres (ALT) mechanism leads to trimming of telomeres. Beyond its telomeric function, ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1) and CDKN2A. ZBTB48 localizes to chromosome 1p36, a region that is frequently rearranged (leiomyoma & leukaemia) or deleted (neuroblastoma, melanoma, Merkel cell carcinoma, pheochromocytoma, and carcinomas of colon and breast) in different human cancers and therefore might be a putative tumour suppressor, but not without dispute.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within Human ZBTB48 aa 584-633 / 688.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069093
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.16-Aminohexadecanoic acid Chemical name Aliquot store at -20℃ or -80℃.4-Bromo-3-ethylbenzonitrile Chemscene Avoid repeated freeze / thaw cycles.PMID:33461415
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 77 kDa
Positive control :
Mouse spleen tissue lysate, HepG2, PC-3M, SH-SY5Y, human liver cancer tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue.