Ernstein); North Georgia Premier Investigation, Dawsonville, GA (Dr W Keating); Alexian Brothers Neurosciences Institute, Elk Grove Village, IL (Dr C Forchetti); Florida Clinical Analysis Centers, Maitland, FL (Dr E Gfeller); Innovative Clinical Ideas, Paducah, KY (Dr W Hogancamp); FS Trials, Dallas, TX (Dr M Downing); and Raleigh Neurology Associates, Raleigh, NC (Dr P Naslund). The authors thank A van der Looij and CRO Premier Research for study coordination; H Derks and R Hobo for data management; F de Vries, J Hendrickx, and W Fan for statistical programming and evaluation; G Witte and R Tooten for laboratory sample management; and Dr IG McKeith, Dr K Rockwood, Dr JWR Twisk and Dr R Witkamp as members on the Independent Information Safety Monitoring Committee. Author facts 1 Rush Alzheimer’s Illness Center, Rush University Healthcare Center, 600 South Paulina, Suite 1022, Chicago, IL 60612, USA. 2Nutricia Sophisticated Health-related Nutrition, Nutricia Research, Uppsalalaan 12, PO Box 80141, 3584TC, Utrecht, the Netherlands. 3Nutricia Investigation, Uppsalalaan 12, PO Box 80141, 3584TC, Utrecht, the Netherlands. 4Department of Neurology, Nova Southeastern University, 33407 North Congress Avenue, West Palm Beach, FL, USA.3-Cyclopropyl-1H-1,2,4-triazole supplier 5 Agewell Health? 46260 North Meridian Street, Indianapolis, IN, USA.96523-46-5 site six Department of Neurology, Oregon Well being and Science University as well as the Portland VA Healthcare Center, 3181 Sw Sam Jackson Park Road, Portland, OR, USA. 7Alzheimer Center, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, the Netherlands. Received: 15 August 2013 Accepted: six November 2013 Published: 26 November14.15. 16. 17. 18.19. 20.21. 22. 23.24. 25.References 1. Alzheimer’s Illness International: Globe Alzheimer Report 2009. London: Alzheimer’s Disease International; 2009. 2. Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ: National Institute on Aging lzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s illness. Alzheimers Dement 2012, eight:1?3. three. Selkoe DJ: Alzheimer’s disease is really a synaptic failure. Science 2002, 298:789?91.PMID:33536087 four. Terry RD: Alzheimer’s illness as well as the aging brain. J Geriatr Psychiatry Neurol 2006, 19:125?28. five. van Wijk N, Broersen LM, de Wilde MC, Hageman RJ, Groenendijk M, Sijben JW, Kamphuis PJ: Targeting synaptic dysfunction in Alzheimer’s illness by administering a particular nutrient mixture. J Alzheimers Dis 2014. 38:459?79. six. Wurtman RJ: Synapse formation and cognitive brain development: effect of docosahexaenoic acid along with other dietary constituents. Metabolism 2008, 57:S6 10. 7. Kamphuis PJ, Scheltens P: Can nutrients protect against or delay onset of Alzheimer’s illness? J Alzheimers Dis 2010, 20:765?75. 8. Scheltens P, Kamphuis PJ, Verhey FR, Olde Rikkert MG, Wurtman RJ, Wilkinson D, Twisk JW, Kurz A: Efficacy of a health-related food in mild Alzheimer’s illness: a randomized, controlled trial. Alzheimers Dement 2010, 6:1?0. e11. 9. Kamphuis PJ, Verhey FR, Olde Rikkert MG, Twisk JW, Swinkels SH, Scheltens P: Efficacy of a healthcare meals on cognition in Alzheimer’s illness: final results from secondary analyses of a randomized, controlled trial. J Nutr Well being Aging 2011, 15:720?24. 10. Scheltens P, Twisk JW, Blesa R, Scarpini E, von Arnim CA, Bongers A, Harrison J, Swinkels SH, Stam CJ, de Waal H, Wurtman RJ, Wieggers RL, Vellas B, Kamphuis PJ: Efficacy of Souvenaid in mild A.