Product Name :
TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0]
Predicted band size :
Observed band size :
Synonyms:
FLJ36137 antibody HMSNP antibody OTTHUMP00000214045 antibody OTTHUMP00000214046 antibody OTTHUMP00000214047 antibody OTTHUMP00000214048 antibody Protein TFG antibody SPG57 antibody TF6 antibody TFG antibody 展开
Function :
Oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, are frequently detected in thyroid carcinomas. Such rearrangements fuse the NTRK1 tyrosine kinase domain to 5′-end sequences of different genes. TRK-T3 contains 1,412 nucleotides of NTRK1 preceded by 598 nucleotides belonging to TFG (TRK-fused gene), a ubiquitously expressed gene located on chromosome 3. The TRK-T3 protein within the TFG region contains a coiled-coil motif that gives the oncoprotein the capability to form complexes. The cytoplasmic TRK-T3 protein binds to and phosphorylates the Shc and SNT1/FRS2 adaptor proteins, both of which are involved in coupling the receptor tyrosine kinase to the mitogen-activated protein kinase pathway by recruiting Grb2/SOS.Zinc(II) difluoromethanesulfinate Chemscene SHP-1 also interacts with and down-regulates TRK-T3.4-Bromo-3-fluoropicolinaldehyde Price
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human TRK aa 351-400 / 400.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, IP
Coupling :
unconjugated
Clone number:
SD082-0
RRID:
AB_3070126
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33414184 Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
43 kDa
Positive control :
293T cell lysate, Hela cell lysate, Hela, SKOV-3, A549, human tonsil tissue, mouse colon tissue, mouse kidney tissue, human lung carcinoma tissue, human kidney tissue.