D activation of Tcf/LEF-1. Thymoquinone (TQ) remedy reduces GSK-3 Ser

D activation of Tcf/LEF-1. Thymoquinone (TQ) therapy decreases GSK-3 Ser9 phosphorylation (downstream of Ras, Raf, MEK) resulting in a relocalization of -catenin to the membrane (green arrows) and reduction of…